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Progestin, the other hormone found in combination pills, is a natural diuretic — meaning that it tends to balance out the effects of the added estrogen. There’s been a ton of research on the birth control pill, and studies have shown that using the birth control pill does not make you gain or lose weight.. I have been on the depo shot for over a year now. But the bottom line is that diet pills are rarely an effective way to lose weight, and they may cause serious health problems, including Can birth control make it hard to lose weight. Fluid retention due to increased salt intake is the common issue found in most woman that rely on birth control. Can Birth Control Pills Make You Gain Weight? Does the pill make you gain weight? Causes. Now that you know the answer to the “What birth control pills make you gain weight?” you are probably thinking about what pills do not make you gain weight. 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